Published : 2015-05-27

NOVEL TRENDS IN ANTIPSYCHOTIC DRUG DEVELOPMENT

Grzegorz Ślifirski

Tomasz Słowiński

Jacek Stefanowicz

Abstract

Schizophrenia is a severe, chronic mental illness that affects approximately 1% of the population. It is associated with a shortened lifespan and significant impairments in social and vocational functioning. Multiple domains of symptoms, e.g. positive and negative symptoms as well as cognitive deficits demand a complex approach to treatment. Results of recent large-scale studies comparing the effectiveness of typical versus atypical antipsychotics appear to indicate that second generation agents are neither more effective, nor associated with better cognitive or social outcomes. The rational development of intentionally designed multi-target agents may solve these therapeutic problems, resulting in the next generation of CNS drugs.

Keywords:

atypical antipsychotic drugs, antipsychotics, schizophrenia, single-target agents, multi-target agents



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Ślifirski, G., Słowiński, T., & Stefanowicz, J. (2015). NOVEL TRENDS IN ANTIPSYCHOTIC DRUG DEVELOPMENT. Prospects in Pharmaceutical Sciences, 13(4), 21–27. https://doi.org/10.56782/pps.112

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Editorial Team
Stefana Banacha 1
02-097 Warsaw, Poland
biuletynfarmacji@wum.edu.pl
Publisher:
Medical University of Warsaw
ul. Żwirki i Wigury 61
02-091 Warszawa

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