ARGLABINA – LAKTON SESKWITERPENOWY  O WŁAŚCIWOŚCIACH PRZECIWNOWOTWOROWYCH

Marta Grech-Baran; Agnieszka Pietrosiuk

doi:10.56782/pps.68

Published : 2010-06-29

Vol. 8 No. 3 (2010)

ARGLABIN - SESQUITERPENE LACTONE REVEALING ANTITUMOR ACTIVITY

Marta Grech-Baran

Agnieszka Pietrosiuk

DOI: https://doi.org/10.56782/pps.68

Abstract

This review highlights the present state of knowledge on the biogenesis of sesquiterpene lactones, in particular biological activities and mechanism of action of arglabin, one of the important metabolite of this group. Arglabin - [1(R),10(S)-epoxy-5(S),5(S),7(S)-guaia-3(4),11(13)-dien-6,12-nolid], represents sesquiterpene gamma-lactones of the guaianolides type. This compound occurs in a few species from Artemisia (Asteraceae) genus. It was originally isolated from the flowers heads and leaves of Artemisia glabella Kar. et Kir. Biological studies showed strong anti-inflammatory, but predominantly antitumor activity of arglabin.

Keywords:

Artemisia, sesquiterpene lactones, arglabin, biological activities, antitumor activity

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Grech-Baran, M., & Pietrosiuk, A. (2010). ARGLABIN - SESQUITERPENE LACTONE REVEALING ANTITUMOR ACTIVITY. Prospects in Pharmaceutical Sciences, 8(3), 22–26. https://doi.org/10.56782/pps.68

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References

Newman D.J., Cragg G.M. Natural Product as Sources of New Drugs over the Last 25 Years. Journal of Natural Products, 2007, 70, 461-477. DOI: https://doi.org/10.1021/np068054v

Adekenov S.M., Mukhametzhanov M.N., Kagarlitskii A.D., Kupriyanov A.N. Arglabin - A new sesquiterpene lactone from Artemisia glabella. Chemistry of Natural Compounds, 1982, 18 (5), 23-624. DOI: https://doi.org/10.1007/BF00575063

Ho-Fai W., Brown G.D. Germacranolides from Artemisia myriantha and their conformation. Phytochemistry, 2002, 59 , 529-536. DOI: https://doi.org/10.1016/S0031-9422(01)00479-4

Seidakhmetova R.B., Beisenbaeva A.A., Atazhanova G.A., Suleimenov E.M., Pak R.N., Kulyyasov A.T., Adekenov S.M. Chemical composition and biological activity of the essential oil from Artemisia glabella. Pharmaceutical Chemistry Journal, 2002, 36, 135-138. DOI: https://doi.org/10.1023/A:1019630327576

Rodriguez E., Towers G.H.N., Mitchelli J.C. Biological activites of sesqiterpene lactones. Phytochemistry, 1976, 15, 1573-1579. DOI: https://doi.org/10.1016/S0031-9422(00)97430-2

Kisiel W. Laktony seskwiterpenowe w chemotaksonomii Compositae. Wiadomości Botaniczne, 1990, 34 (1), 13-18.

Herz W., Heywood V.H., Harborne J.B., Turner B.L. The biology and chemistry of the Compositae. Academic Press, London, 1977, 11, 337-338.

Kisiel W. Laktony seskwiterpenowe o działaniu przeciwzapalnym w roślinach leczniczych. Wiadomości Zielarskie, 1995, 7/8, 24-25.37.

Suleimenov E.M., Smagulova F.M., Morozova O.V., Raldugin V.A., Bagryanskaya I.Yu., Gatilov Yu.V., Yamovoi V.I., Adekenov S.M. Sesquiterpene lactones and flavonoids from Artemisia albida. Chemistry of Natural Compounds 2005, 41 (6), 689-691. DOI: https://doi.org/10.1007/s10600-006-0013-x

Suleimenov E.M., Raldugin V.A., Adekenov S.M. Anhydroaustricin from Artemisia albida. Chemistry of Natural Compounds, 2008, 44 (4), 541-542. DOI: https://doi.org/10.1007/s10600-008-9118-8

Adekenov, S.M., Turdybekov, K.M., Aituganoav, K.A., Lindeman, S.V., Struchkov, Yu.T., Shaltakov, S.N. 1β,10α- dihydroxyarglabin- a new sesquiterpene lactone from Artemisia glabella. Chemistry of Natural Compounds, 1993, 29 (6), 735-739. DOI: https://doi.org/10.1007/BF00629642

Kalidindi S., Leong W.B., Schall A., Bandichhor R., Nosse B., Enantioselective synthesis of arglabin . Angewandte Chemie, 2007, 46, 6361-6363. DOI: https://doi.org/10.1002/anie.200701584

Dzhalmakhanbetova R.I., Kuliasov, Adekenow S.M., Raldugin V.A., Bagryanskaya Yu.V., Shakirov M. The 2nd International Conference on Natural Products and Physiologically Active Substances. Novosibirsk. 2004, 64- 65.

Jalmakhanbetova R.I., Atazhanova G.A., Raldugin V.A., Bagryanskaya Yu.V., Gatilov M., Adekenov S.M. Crystal structure of a tetrabromo derivative of cyclopropyldihydroarglabin and its antifungal activity. Chemistry of Natural Compounds, 2006, 42 (3), 307-309. DOI: https://doi.org/10.1007/s10600-006-0106-6

Jalmakhanbetova R.I., Atazhanova G.A., Raldugin V.A., Bagryanskaya Yu.V., Adekenov S.M., Preparation and structure elucidation of two minor products from reaction of arglabin with chloroform in the presence of a crown ether. Chemistry of Natural Compounds, 2007, 43 (5), 548-551. DOI: https://doi.org/10.1007/s10600-007-0188-9

Jalmahanbetova R.I., Rakhimova B.B., Raldugin.V.A., Bagryanskaya I.Yu., Gatilov V., Shakirov M.M., Kulyjasov A.T. Adekenov S.M., Tolstikov G.A. First synthesis of dialkyl phosphonate derivates of sesquiterpene α-methylene-γ-lactone. Russian Chemical Bulletin, International Edition, 2003, 52, 748-751. DOI: https://doi.org/10.1002/chin.200341192

Shaikenov T.E., Adekenov S.M., Williams R.M., Prashad N., Baker F.L., Madden T.L., Newman R. Arglabin-DMA, a plant derived sesquiterpene, inhibits farnesyltransferase. Oncology Reports, 2001, 8 (1),173-179. DOI: https://doi.org/10.3892/or.8.1.173

Zhangabylov N.S., Dederer L. Yu., Gorbacheva L.B., Vasil`eva S.V., Adekenov S.M. Sesquiterpene lactone arglabin influences DNA synthesis in P388 leukemia cells in vivo. Pharmaceutical Chemistry Journal, 2004, 38, 651-653. DOI: https://doi.org/10.1007/s11094-005-0052-9

Bottex-Gauthier C, Vidal D, Picot F, Potier P, Menichini F, Appendino G. In vitro biological activities of arglabin a sesquiterpene lactone from the Chinese herb Artemisia myriantha Wall. Biotechnol Ther., 1993, 4 (1-2), 77-98.

Korycka A., Góra-Tybor J., Robak T. Farmakologia i perspektywy klinicznego zastosowania inhibitora białkowej farnezylotransferazy RI 15777. Acta Haematologica Polonica, 2001, 32, 4,367-374.

End D.W. Farnesyl protein transferase inhibitors and other therapies targeting the Ras signal transduction pathway. Investigational New Drugs, 1999, 17, 241-258. DOI: https://doi.org/10.1023/A:1006380320290

Marta Grech-Baran

Affiliation:

Katedra i Zakład Biologii i Botaniki Farmaceutycznej, Wydział Farmaceutyczny, Warszawski Uniwersytet Medyczny, Poland

Agnieszka Pietrosiuk

Affiliation:

Katedra i Zakład Biologii i Botaniki Farmaceutycznej, Wydział Farmaceutyczny, Warszawski Uniwersytet Medyczny, Poland

ARGLABIN - SESQUITERPENE LACTONE REVEALING ANTITUMOR ACTIVITY

Marta Grech-Baran

Agnieszka Pietrosiuk

Abstract

Keywords:

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