EGZOSOMY JAKO NOŚNIKI INFORMACJI W KOMUNIKACJI MIĘDZY KOMÓRKAMI NOWOTWOROWYMI

Aleksandra Grzybowska; Tomasz Lorenc; Wioletta Olejarz; Grażyna Nowicka

doi:10.56782/pps.32

Data publikacji : 2019-08-07

Tom 17 Nr 2 (2019)

EGZOSOMY JAKO NOŚNIKI INFORMACJI W KOMUNIKACJI MIĘDZY KOMÓRKAMI NOWOTWOROWYMI

Aleksandra Grzybowska

Tomasz Lorenc

Wioletta Olejarz

Grażyna Nowicka

DOI: https://doi.org/10.56782/pps.32

Abstrakt

Egzosomy to sferyczne nanopęcherzyki błonowe uwalniane niemal przez wszystkie typy komórek. Jako struktury zawierające bogaty panel bioaktywnych cząsteczek pośredniczą w wymianie informacji oraz transporcie składników między komórkami, inicjując lub modulując określone procesy, zarówno fizjologiczne, jak i patologiczne. Egzosomy posiadają ogromny potencjał do wykorzystania ich w diagnostyce, zapobieganiu oraz leczeniu wielu chorób, w tym nowotworów. W pracy przedstawiono aktualną wiedzę na temat egzosomów, uwzględniając w szczególności ich rolę w komunikacji między komórkami nowotworowymi oraz możliwości zastosowania w diagnostyce oraz terapii onkologicznej.

Słowa kluczowe:

egzosomy, zewnątrzkomórkowe pęcherzyki błonowe, biomarkery, komunikacja międzykomórkowa, nowotwór, leki onkologiczne

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Grzybowska, A., Lorenc, T., Olejarz, W., & Nowicka, G. (2019). EGZOSOMY JAKO NOŚNIKI INFORMACJI W KOMUNIKACJI MIĘDZY KOMÓRKAMI NOWOTWOROWYMI. Prospects in Pharmaceutical Sciences, 17(2), 6–13. https://doi.org/10.56782/pps.32

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Utwór dostępny jest na licencji Creative Commons Uznanie autorstwa 4.0 Międzynarodowe.

Bibliografia

Zhang C, Ji Q, Yang Y, Li Q, Wang Z, Exosome: Function and Role in Cancer Metastasis and Drug Resistance, Technol Cancer Res Treat, 2018, 17, 1-12. DOI: https://doi.org/10.1177/1533033818763450

Cai C, Koch B, Morikawa K, Suda G, Sakamoto N, Rueschenbaum S, Akhras S, Dietz J, Hildt E, Zeuzem S, Welsch C, Lange CM, Macrophage-Derived Extracellular Vesicles Induce Long-Lasting Immunity Against Hepatitis C Virus Which Is Blunted by Polyunsaturated Fatty Acids, Front Immunol, 2018, 9, 723. DOI: https://doi.org/10.3389/fimmu.2018.00723

Couto N, Caja S, Maia J, Strano Moraes MC, Costa-Silva B, Exosomes as emerging players in cancer biology, Biochimie, 2018, 155, 2-10. DOI: https://doi.org/10.1016/j.biochi.2018.03.006

Bakhshian Nik A, Hutcheson JD, Aikawa E, Extracellular Vesicles As Mediators of Cardiovascular Calcification, Front Cardiovasc Med, 2017, 4, 78. DOI: https://doi.org/10.3389/fcvm.2017.00078

Xian X, Gong Q, Li C, Guo B, Jiang H, Exosomes with Highly Angiogenic Potential for Possible Use in Pulp Regeneration, J Endod, 2018, 44, 751-758. DOI: https://doi.org/10.1016/j.joen.2017.12.024

Vlaeminck-Guillem V, Extracellular Vesicles in Prostate Cancer Carcinogenesis, Diagnosis, and Management, Front Oncol, 2018, 8, 222. DOI: https://doi.org/10.3389/fonc.2018.00222

Bobrie A, Colombo M, Raposo G, Thery C, Exosome secretion: molecular mechanisms and roles in immune responses, Traffic, 2011, 12, 1659-1668. DOI: https://doi.org/10.1111/j.1600-0854.2011.01225.x

McBride JD, Rodriguez-Menocal L, Badiavas EV, Extracellular Vesicles as Biomarkers and Therapeutics in Dermatology: A Focus on Exosomes, J Invest Dermatol, 2017, 137, 1622-1629. DOI: https://doi.org/10.1016/j.jid.2017.04.021

Machtinger R, Laurent LC, Baccarelli AA, Extracellular vesicles: roles in gamete maturation, fertilization and embryo implantation, Hum Reprod Update, 2016, 22, 182-193. DOI: https://doi.org/10.1093/humupd/dmv055

Wojtowicz A, Baj-Krzyworzeka M, Baran J, Characterization and biological role of extracellular vesicles, Postepy Hig Med Dosw, 2014, 68, 1421-1432. DOI: https://doi.org/10.5604/17322693.1130655

Wang J, Sun X, Zhao J, Yang Y, Cai X, Xu J, Cao P, Exosomes: A Novel Strategy for Treatment and Prevention of Diseases, Front Pharmacol, 2017, 8, 300. DOI: https://doi.org/10.3389/fphar.2017.00300

Urbanelli L, Magini A, Buratta S, Brozzi A, Sagini K, Polchi A, Tancini B, Emiliani C, Signaling pathways in exosomes biogenesis, secretion and fate, Genes (Basel), 2013, 4, 152-170. DOI: https://doi.org/10.3390/genes4020152

Stahl PD, Raposo G, Exosomes and extracellular vesicles: the path forward, Essays Biochem, 2018, 62, 119-124. DOI: https://doi.org/10.1042/EBC20170088

Savina A, Fader CM, Damiani MT, Colombo MI, Rab11 promotes docking and fusion of multivesicular bodies in a calcium-dependent manner, Traffic, 2005, 6, 131-143. DOI: https://doi.org/10.1111/j.1600-0854.2004.00257.x

Hsu C, Morohashi Y, Yoshimura S, Manrique-Hoyos N, Jung S, Lauterbach MA, Bakhti M, Gronborg M, Mobius W, Rhee J, Barr FA, Simons M, Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C, J Cell Biol, 2010, 189, 223-232. DOI: https://doi.org/10.1083/jcb.200911018

Ostrowski M, Carmo NB, Krumeich S, Fanget I, Raposo G, Savina A, Moita CF, Schauer K, Hume AN, Freitas RP, Goud B, Benaroch P, Hacohen N, Fukuda M, Desnos C, Seabra MC, Darchen F, Amigorena S, Moita LF, Thery C, Rab27a and Rab27b control different steps of the exosome secretion pathway, Nat Cell Biol, 2010, 12, 19-30; sup pp 11-13. DOI: https://doi.org/10.1038/ncb2000

Hemler ME, Tetraspanin proteins mediate cellular penetration, invasion, and fusion events and define a novel type of membrane microdomain, Annu Rev Cell Dev Biol, 2003, 19, 397-422. DOI: https://doi.org/10.1146/annurev.cellbio.19.111301.153609

Kharaziha P, Ceder S, Li Q, Panaretakis T, Tumor cell-derived exosomes: a message in a bottle, Biochim Biophys Acta, 2012, 1826, 103-111. DOI: https://doi.org/10.1016/j.bbcan.2012.03.006

Brouwers JF, Aalberts M, Jansen JW, van Niel G, Wauben MH, Stout TA, Helms JB, Stoorvogel W, Distinct lipid compositions of two types of human prostasomes, Proteomics, 2013, 13, 1660-1666. DOI: https://doi.org/10.1002/pmic.201200348

Lobb RJ, Becker M, Wen SW, Wong CS, Wiegmans AP, Leimgruber A, Moller A, Optimized exosome isolation protocol for cell culture supernatant and human plasma, J Extracell Vesicles, 2015, 4, 27031. DOI: https://doi.org/10.3402/jev.v4.27031

Soung YH, Ford S, Zhang V, Chung J, Exosomes in Cancer Diagnostics, Cancers (Basel), 2017, 9, 8. DOI: https://doi.org/10.3390/cancers9010008

Wesolowska A, Piwocka K, Exosomal microRNAs as a part of the cell-cell communication in cancer, Postepy Biochem, 2017, 63, 110-118.

Lu M, Xing H, Yang Z, Sun Y, Yang T, Zhao X, Cai C, Wang D, Ding P, Recent advances on extracellular vesicles in therapeutic delivery: Challenges, solutions, and opportunities, Eur J Pharm Biopharm, 2017, 119, 381-395. DOI: https://doi.org/10.1016/j.ejpb.2017.07.010

P. W, The nature and significance of platelet products in human plasma, Br J Haematol, 1967 13, 269-288. DOI: https://doi.org/10.1111/j.1365-2141.1967.tb08741.x

Mathivanan S, Simpson RJ, ExoCarta: A compendium of exosomal proteins and RNA, Proteomics, 2009, 9, 4997-5000. DOI: https://doi.org/10.1002/pmic.200900351

De Toro J, Herschlik L, Waldner C, Mongini C, Emerging roles of exosomes in normal and pathological conditions: new insights for diagnosis and therapeutic applications, Front Immunol, 2015, 6, 203. DOI: https://doi.org/10.3389/fimmu.2015.00203

Guescini M, Genedani S, Stocchi V, Agnati LF, Astrocytes and Glioblastoma cells release exosomes carrying mtDNA, J Neural Transm (Vienna), 2010, 117, 1-4. DOI: https://doi.org/10.1007/s00702-009-0288-8

Guescini M, Guidolin D, Vallorani L, Casadei L, Gioacchini AM, Tibollo P, Battistelli M, Falcieri E, Battistin L, Agnati LF, Stocchi V, C2C12 myoblasts release micro-vesicles containing mtDNA and proteins involved in signal transduction, Exp Cell Res, 2010, 316, 1977-1984. DOI: https://doi.org/10.1016/j.yexcr.2010.04.006

Li P, Kaslan M, Lee SH, Yao J, Gao Z, Progress in Exosome Isolation Techniques, Theranostics, 2017, 7, 789-804. DOI: https://doi.org/10.7150/thno.18133

Carretero-Gonzalez A, Otero I, Carril-Ajuria L, de Velasco G, Manso L, Exosomes: Definition, Role in Tumor Development and Clinical Implications, Cancer Microenviron, 2018, 11, 13-21. DOI: https://doi.org/10.1007/s12307-018-0211-7

Athman JJ, Wang Y, McDonald DJ, Boom WH, Harding CV, Wearsch PA, Bacterial Membrane Vesicles Mediate the Release of Mycobacterium tuberculosis Lipoglycans and Lipoproteins from Infected Macrophages, J Immunol, 2015, 195, 1044-1053. DOI: https://doi.org/10.4049/jimmunol.1402894

Jones LB, Bell CR, Bibb KE, Gu L, Coats MT, Matthews QL, Pathogens and Their Effect on Exosome Biogenesis and Composition, Biomedicines, 2018, 6. DOI: https://doi.org/10.3390/biomedicines6030079

Anand D, Chaudhuri A, Bacterial outer membrane vesicles: New insights and applications, Mol Membr Biol, 2016, 33, 125-137. DOI: https://doi.org/10.1080/09687688.2017.1400602

Atayde VD, Hassani K, da Silva Lira Filho A, Borges AR, Adhikari A, Martel C, Olivier M, Leishmania exosomes and other virulence factors: Impact on innate immune response and macrophage functions, Cell Immunol, 2016, 309, 7-18. DOI: https://doi.org/10.1016/j.cellimm.2016.07.013

Quintana JF, Babayan SA, Buck AH, Small RNAs and extracellular vesicles in filarial nematodes: From nematode development to diagnostics, Parasite Immunol, 2017, 39. DOI: https://doi.org/10.1111/pim.12395

Hartmann A, Muth C, Dabrowski O, Krasemann S, Glatzel M, Exosomes and the Prion Protein: More than One Truth, Front Neurosci, 2017, 11, 194. DOI: https://doi.org/10.3389/fnins.2017.00194

Masrour-Roudsari J, Ebrahimpour S, Causal role of infectious agents in cancer: An overview, Caspian J Intern Med, 2017, 8, 153-158.

Paavonen J, Karunakaran KP, Noguchi Y, Anttila T, Bloigu A, Dillner J, Hallmans G, Hakulinen T, Jellum E, Koskela P, Lehtinen M, Thoresen S, Lam H, Shen C, Brunham RC, Serum antibody response to the heat shock protein 60 of Chlamydia trachomatis in women with developing cervical cancer, Am J Obstet Gynecol, 2003, 189, 1287-1292. DOI: https://doi.org/10.1067/S0002-9378(03)00755-5

Wu J, Yang J, Ding J, Guo X, Zhu XQ, Zheng Y, Exosomes in virus-associated cancer, Cancer Lett, 2018, 438, 44-51. DOI: https://doi.org/10.1016/j.canlet.2018.09.018

Melo SA, Sugimoto H, O'Connell JT, Kato N, Villanueva A, Vidal A, Qiu L, Vitkin E, Perelman LT, Melo CA, Lucci A, Ivan C, Calin GA, Kalluri R, Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis, Cancer Cell, 2014, 26, 707-721. DOI: https://doi.org/10.1016/j.ccell.2014.09.005

Cui H, Seubert B, Stahl E, Dietz H, Reuning U, Moreno-Leon L, Ilie M, Hofman P, Nagase H, Mari B, Kruger A, Tissue inhibitor of metalloproteinases-1 induces a pro-tumourigenic increase of miR-210 in lung adenocarcinoma cells and their exosomes, Oncogene, 2015, 34, 3640-3650. DOI: https://doi.org/10.1038/onc.2014.300

Hoshino A, Costa-Silva B, Shen TL, Rodrigues G, Hashimoto A, Tesic Mark M, Molina H, Kohsaka S, Di Giannatale A, Ceder S, Singh S, Williams C, Soplop N, Uryu K, Pharmer L, King T, Bojmar L, Davies AE, Ararso Y, Zhang T, Zhang H, Hernandez J, Weiss JM, Dumont-Cole VD, Kramer K, Wexler LH, Narendran A, Schwartz GK, Healey JH, Sandstrom P, Labori KJ, Kure EH, Grandgenett PM, Hollingsworth MA, de Sousa M, Kaur S, Jain M, Mallya K, Batra SK, Jarnagin WR, Brady MS, Fodstad O, Muller V, Pantel K, Minn AJ, Bissell MJ, Garcia BA, Kang Y, Rajasekhar VK, Ghajar CM, Matei I, Peinado H, Bromberg J, Lyden D, Tumour exosome integrins determine organotropic metastasis, Nature, 2015, 527, 329-335. DOI: https://doi.org/10.1038/nature15756

Clark DJ, Fondrie WE, Yang A, Mao L, Triple SILAC quantitative proteomic analysis reveals differential abundance of cell signaling proteins between normal and lung cancer-derived exosomes, J Proteomics, 2016, 133, 161-169. DOI: https://doi.org/10.1016/j.jprot.2015.12.023

Abdouh M, Hamam D, Gao ZH, Arena V, Arena M, Arena GO, Exosomes isolated from cancer patients' sera transfer malignant traits and confer the same phenotype of primary tumors to oncosuppressor-mutated cells, J Exp Clin Cancer Res, 2017, 36, 113. DOI: https://doi.org/10.1186/s13046-017-0587-0

Liu Y, Xiang X, Zhuang X, Zhang S, Liu C, Cheng Z, Michalek S, Grizzle W, Zhang HG, Contribution of MyD88 to the tumor exosome-mediated induction of myeloid derived suppressor cells, Am J Pathol, 2010, 176, 2490-2499. DOI: https://doi.org/10.2353/ajpath.2010.090777

Giovannetti E, van der Borden CL, Frampton AE, Ali A, Firuzi O, Peters GJ, Never let it go: Stopping key mechanisms underlying metastasis to fight pancreatic cancer, Semin Cancer Biol, 2017, 44, 43-59. DOI: https://doi.org/10.1016/j.semcancer.2017.04.006

Lv LH, Wan YL, Lin Y, Zhang W, Yang M, Li GL, Lin HM, Shang CZ, Chen YJ, Min J, Anticancer drugs cause release of exosomes with heat shock proteins from human hepatocellular carcinoma cells that elicit effective natural killer cell antitumor responses in vitro, J Biol Chem, 2012, 287, 15874-15885. DOI: https://doi.org/10.1074/jbc.M112.340588

Wen SW, Sceneay J, Lima LG, Wong CS, Becker M, Krumeich S, Lobb RJ, Castillo V, Wong KN, Ellis S, Parker BS, Moller A, The Biodistribution and Immune Suppressive Effects of Breast Cancer-Derived Exosomes, Cancer Res, 2016, 76, 6816-6827. DOI: https://doi.org/10.1158/0008-5472.CAN-16-0868

Klibi J, Niki T, Riedel A, Pioche-Durieu C, Souquere S, Rubinstein E, Le Moulec S, Guigay J, Hirashima M, Guemira F, Adhikary D, Mautner J, Busson P, Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells, Blood, 2009, 113, 1957-1966. DOI: https://doi.org/10.1182/blood-2008-02-142596

Soderberg A, Barral AM, Soderstrom M, Sander B, Rosen A, Redox-signaling transmitted in trans to neighboring cells by melanoma-derived TNF-containing exosomes, Free Radic Biol Med, 2007, 43, 90-99. DOI: https://doi.org/10.1016/j.freeradbiomed.2007.03.026

Song J, Chen X, Wang M, Xing Y, Zheng Z, Hu S, Cardiac endothelial cell-derived exosomes induce specific regulatory B cells, Sci Rep, 2014, 4, 7583. DOI: https://doi.org/10.1038/srep07583

Di Bonito P, Ridolfi B, Columba-Cabezas S, Giovannelli A, Chiozzini C, Manfredi F, Anticoli S, Arenaccio C, Federico M, HPV-E7 delivered by engineered exosomes elicits a protective CD8(+) T cell-mediated immune response, Viruses, 2015, 7, 1079-1099. DOI: https://doi.org/10.3390/v7031079

Ciravolo V, Huber V, Ghedini GC, Venturelli E, Bianchi F, Campiglio M, Morelli D, Villa A, Della Mina P, Menard S, Filipazzi P, Rivoltini L, Tagliabue E, Pupa SM, Potential role of HER2-overexpressing exosomes in countering trastuzumab-based therapy, J Cell Physiol, 2012, 227, 658-667. DOI: https://doi.org/10.1002/jcp.22773

Safaei R, Larson BJ, Cheng TC, Gibson MA, Otani S, Naerdemann W, Howell SB, Abnormal lysosomal trafficking and enhanced exosomal export of cisplatin in drug-resistant human ovarian carcinoma cells, Mol Cancer Ther, 2005, 4, 1595-1604. DOI: https://doi.org/10.1158/1535-7163.MCT-05-0102

Rak J, Extracellular vesicles - biomarkers and effectors of the cellular interactome in cancer, Front Pharmacol, 2013, 4, 21. DOI: https://doi.org/10.3389/fphar.2013.00021

Tang MK, Wong AS, Exosomes: Emerging biomarkers and targets for ovarian cancer, Cancer Lett, 2015, 367, 26-33. DOI: https://doi.org/10.1016/j.canlet.2015.07.014

Li Y, Zheng Q, Bao C, Li S, Guo W, Zhao J, Chen D, Gu J, He X, Huang S, Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis, Cell Res, 2015, 25, 981-984. DOI: https://doi.org/10.1038/cr.2015.82

Zhao Z, Yang Y, Zeng Y, He M, A microfluidic ExoSearch chip for multiplexed exosome detection towards blood-based ovarian cancer diagnosis, Lab Chip, 2016, 16, 489-496. DOI: https://doi.org/10.1039/C5LC01117E

Rupp AK, Rupp C, Keller S, Brase JC, Ehehalt R, Fogel M, Moldenhauer G, Marme F, Sultmann H, Altevogt P, Loss of EpCAM expression in breast cancer derived serum exosomes: role of proteolytic cleavage, Gynecol Oncol, 2011, 122, 437-446. DOI: https://doi.org/10.1016/j.ygyno.2011.04.035

Ye SB, Zhang H, Cai TT, Liu YN, Ni JJ, He J, Peng JY, Chen QY, Mo HY, Jun C, Zhang XS, Zeng YX, Li J, Exosomal miR-24-3p impedes T-cell function by targeting FGF11 and serves as a potential prognostic biomarker for nasopharyngeal carcinoma, J Pathol, 2016, 240, 329-340. DOI: https://doi.org/10.1002/path.4781

Lugini L, Cecchetti S, Huber V, Luciani F, Macchia G, Spadaro F, Paris L, Abalsamo L, Colone M, Molinari A, Podo F, Rivoltini L, Ramoni C, Fais S, Immune surveillance properties of human NK cell-derived exosomes, J Immunol, 2012, 189, 2833-2842. DOI: https://doi.org/10.4049/jimmunol.1101988

Pitt JM, Andre F, Amigorena S, Soria JC, Eggermont A, Kroemer G, Zitvogel L, Dendritic cell-derived exosomes for cancer therapy, J Clin Invest, 2016, 126, 1224-1232. DOI: https://doi.org/10.1172/JCI81137

Li R, Chibbar R, Xiang J, Novel EXO-T vaccine using polyclonal CD4(+) T cells armed with HER2-specific exosomes for HER2-positive breast cancer, Onco Targets Ther, 2018, 11, 7089-7093. DOI: https://doi.org/10.2147/OTT.S184898

Gilligan KE, Dwyer RM, Engineering Exosomes for Cancer Therapy, Int J Mol Sci, 2017, 18, 1122. DOI: https://doi.org/10.3390/ijms18061122

Agrawal AK, Aqil F, Jeyabalan J, Spencer WA, Beck J, Gachuki BW, Alhakeem SS, Oben K, Munagala R, Bondada S, Gupta RC, Milk-derived exosomes for oral delivery of paclitaxel, Nanomedicine, 2017, 13, 1627-1636. DOI: https://doi.org/10.1016/j.nano.2017.03.001

Federici C, Petrucci F, Caimi S, Cesolini A, Logozzi M, Borghi M, D'Ilio S, Lugini L, Violante N, Azzarito T, Majorani C, Brambilla D, Fais S, Exosome release and low pH belong to a framework of resistance of human melanoma cells to cisplatin, PLoS One, 2014, 9, e88193. DOI: https://doi.org/10.1371/journal.pone.0088193

Jang SC, Kim OY, Yoon CM, Choi DS, Roh TY, Park J, Nilsson J, Lotvall J, Kim YK, Gho YS, Bioinspired exosome-mimetic nanovesicles for targeted delivery of chemotherapeutics to malignant tumors, ACS Nano, 2013, 7, 7698-7710. DOI: https://doi.org/10.1021/nn402232g