Experimental investigation of Cynodon dactylon ethanolic extract against allergic conjunctivitis in rats

Arvind Kumar Patel; Phool Chandra; Neetu Sachan; Neha Singh; Vidhan Chand Bala; Shivam Kumar

doi:10.56782/pps.413

Published : 2025-07-22

Vol. 23 No. 3 (2025)

Experimental investigation of Cynodon dactylon ethanolic extract against allergic conjunctivitis in rats

Arvind Kumar Patel

Phool Chandra

Neetu Sachan

Neha Singh

Vidhan Chand Bala

Shivam Kumar

DOI: https://doi.org/10.56782/pps.413

Abstract

Allergic conjunctivitis refers to inflammation of the conjunctiva, often treated with allopathic drugs that may cause side effects. Plant-based preparations are considered safer alternatives; therefore, this study aims to evaluate the anti-allergic conjunctivitis effect of ethanolic extract of Cynodon dactylon (EECD) in rats. The allergic conjunctivitis was induced in the rats, for that we administered the 0.6 ml of saline solution which contains 10¹⁰killed Bordetella pertussis cells, aluminium hydroxide (2 mg) and egg albumin (1 mg) by intra-peritoneal injection on the first day. On 5^th day we administered egg albumin (0.5 mg) in 1 ml saline solution subcutaneously at 10 places on the back side of rats. The rats were then given extracts (EECD) at 100 mg/kg, 200 mg/kg, and 400 mg/kg given orally, corresponding to their group from days 14 to 42. In contrast, the standard group received treatment with cetirizine hydrochloride at a dose of 10 mg/kg p.o., whereas 1% w/v carboxymethyl cellulose (CMC) solution was given to the control group. Five microliters of egg albumin in a physiological solution (10 mg/ml) were administered an hour after the dose via micropipette into each of the eyes to achieve local sensitization. Subsequently, the number of eye scratching behaviour was counted for five minutes following local sensitization, while allergic symptoms, such as conjunctival hyperemia and edema, were noted at five and twenty minutes, respectively. In the results we found that, treatment with the ethanolic extract of Cynodon dactylon at 200 and 400 mg/kg significantly decreased (p<0.001) allergy symptoms and eye scratching behaviour and its effects were found in dose dependent manner. Based on the current investigation, it was concluded that the ethanolic extract of Cynodon dactylon significantly reduced the signs of conjunctivitis caused by allergies.

Keywords:

Cynodon dactylon, Antioxidants, Anti-allergic conjunctivitis, Allergic symptoms, Eye scratching behaviours, Cetirizine hydrochloride

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Kumar Patel, A., Chandra, P., Sachan, N., Singh, N., Bala, V. C., & Kumar, S. (2025). Experimental investigation of Cynodon dactylon ethanolic extract against allergic conjunctivitis in rats. Prospects in Pharmaceutical Sciences, 23(3), 29–35. https://doi.org/10.56782/pps.413

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Arvind Kumar Patel

akpatel4393@gmail.com
https://orcid.org/0000-0002-6100-8861

Affiliation:

Narayan Institute of Pharmacy, Gopal Narayan Singh University, Jamuhar, Sasaram, Rohtas- 821305 (Bihar), India India

Phool Chandra

profpcpatel@gmail.com

Affiliation:

Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad-244001 (UP), India India

Neetu Sachan

profneetusachan@gmail.com

Affiliation:

Maharana Pratap College of Pharmacy, Kothi, Mandhana, Kanpur-209217 (UP), India India

Neha Singh

nehakit2016@gmail.com

Affiliation:

Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad-244 001 (UP), India India

Vidhan Chand Bala

vidhanchandbala07@gmail.com

Affiliation:

School of Pharmaceutical Sciences, IFTM University, Lodhipur Rajput, Moradabad-821305 (UP), India India

Shivam Kumar

shiv15gulshan@gmail.com

Affiliation:

Narayan Institute of Pharmacy, Gopal Narayan Singh University, Jamuhar, Sasaram, Rohtas- 821305 (Bihar), India India

Experimental investigation of Cynodon dactylon ethanolic extract against allergic conjunctivitis in rats

Arvind Kumar Patel

Phool Chandra

Neetu Sachan

Neha Singh

Vidhan Chand Bala

Shivam Kumar

Abstract

Keywords:

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