English
Simultaneous Determination of Pharmaceuticals Using Two UV-Based Methods with Different Diluents: Comparative Analysis via ANOVA and Greenness Assessment
Prapti Gawand
Reshma Jadhav
Ashish Jain
Priya Jagtap
Bhavesh Mahajan
Prathamesh Chaudhari
Vijay Jadhav
Namrata Mahajan
Abstract
In this work, a UV spectrophotometric approach that is accurate, precise, and environmentally friendly Is proposed for concurrent quantification of Ritonavir and Nirmatrelvir in combination pharmaceutical form. While treating COVID-19, these antiviral medications are essential. The Q-absorbance method was created and validated in accordance with ICH criteria, and the simultaneous estimation method is constructed utilizing two distinct solvents. After being evaluated for linearity, accuracy, precision, robustness, and sensitivity, the suggested techniques showed great reproducibility and high correlation coefficients (r2 = 0.999). One-way ANOVA statistical comparison verified that the devised methodologies were reliable and consistent for pharmaceutical analysis, with no significant differences found.Furthermore, the Green Analytical Procedure Index (GAPI), AGREE, and BAGI criteria were used to assess the Ecological sustainability of these methods. The results demonstrated that the suggested approaches provide a greener substitute for traditional analytical procedures by drastically lowering solvent usage and the production of hazardous waste. The proposed UV spectrophotometric approaches offer a straightforward, economical, and dependable solution for the routine quality evaluation of Ritonavir and Nirmatrelvir in dosage forms.
Keywords:
UV spectrophotometric approach, Antiviral medications, One way ANOVA, Environmental sustainabilityMost read articles by the same author(s)
- Prathamesh V Chaudhari, Reshma Jadhav, Ashish Jain, Priya D Jagtap, Bhavesh D Mahajan, Prapti Gawand, A comprehensive review on drug-induced diseases and teratogenicity , Prospects in Pharmaceutical Sciences: Vol. 23 No. 1 (2025)
- Priya Jagtap, Dr. Reshma Jadhav, Dr. Ashish Jain, Bhavesh Mahajan, Prapti Gawand, Prathamesh Chaudhari, Aishwarya Patil, QUALITY BY DESIGN APPROACH IN HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS DETERMINATION OF ABIRATERONE ACETATE AND PREDNISOLONE WITH GREENNESS ASSESSMENT , Prospects in Pharmaceutical Sciences: No. 2025 (Early Access)
- Swati Pawar, Vishnu P Choudhari, Deepak Jha, Bhanudas Kuchekar, Reshma Jadhav, Isolation and characterization of β-sitosterol and β-citraurin from saponified paprika oleoresin , Prospects in Pharmaceutical Sciences: Vol. 23 No. 1 (2025)
Similar Articles
- Olga Grelewicz, Gabriela Kulbacka, Tomasz Mikuła, Alicja Wiercińska-Drapało, Does testosterone intake affect diagnosing primary HIV infection? , Prospects in Pharmaceutical Sciences: Vol. 21 No. 1 (2023)
- Dibyajyoti Saha, Satish Kumar Sarankar, Critical review on potentials of ethnopharmacological, ethnomedicinal and traditional practices of Madhuca longifolia (J. Koenig Ex L.) J. F. Macbr. (Family: Sapotaceae) , Prospects in Pharmaceutical Sciences: Vol. 21 No. 2 (2023)
- Mustafa Sevindik, Celal Bal, Emre Cem Eraslan, İmran Uysal, Falah Saleh Mohammed, Medicinal mushrooms: a comprehensive study on their antiviral potential , Prospects in Pharmaceutical Sciences: Vol. 21 No. 2 (2023)
- Daria Żuraw, Paulina Oleksa, Mateusz Sobczyk, Kacper Jasiński, Simple obesity in children , Prospects in Pharmaceutical Sciences: Vol. 21 No. 2 (2023)
- Elżbieta Gniazdowska, Edyta Gilant, Katarzyna Buś-Kwaśnik, ICH M10 guideline - a harmonized global approach to bioanalysis , Prospects in Pharmaceutical Sciences: Vol. 21 No. 3 (2023)
- Michał Gackowski, Katarzyna Połomska, Natalia Szczucka, Mateusz Wylaź, Digital-based system as a tool for improving healthcare coordination - a perspective study , Prospects in Pharmaceutical Sciences: Vol. 22 No. 2 (2024)
- Mateusz Kawka, Maciej Pilarek, Katarzyna Sykłowska-Baranek, Agnieszka Pietrosiuk, ROŚLINNE METABOLITY JAKO KLUCZOWY BIOPRODUKT BIOTECHNOLOGII ROŚLIN , Prospects in Pharmaceutical Sciences: Vol. 15 No. 8 (2017)
- Jakub Starownik, Maciej Bara, Jakub Szydło, Patryk Gryszkiewicz, Jakub Nieznański, Review of available drugs and non-pharmacological strategies used to treat insomnia , Prospects in Pharmaceutical Sciences: Vol. 23 No. 2 (2025)
- Aleksandra Grzybowska, Tomasz Lorenc, Wioletta Olejarz, Grażyna Nowicka, EXOSOMES AS CARRIERS OF INFORMATION BEETWEN TUMOR CELLS , Prospects in Pharmaceutical Sciences: Vol. 17 No. 2 (2019)
You may also start an advanced similarity search for this article.
Details
References
Statistics
Authors
Citation rules
Cited by / Share
Licence
This work is licensed under a Creative Commons Attribution 4.0 International License.