EFFECT OF DNA METHYLATION ON GENOME FUNCTION
DOI:
https://doi.org/10.56782/pps.62Keywords:
DNA methylation, genome, imprintingAbstract
In biochemistry, methylation refers to the replacement of a hydrogen atom with a methyl group. DNA methylation is a type of chemical modification of DNA that can be inherited and subsequently removed without changing the original DNA sequence. It has been demonstrated that DNA methylation is involved in a number of biological processes such as parental imprinting, X chromosome inactivation, and development of tumors. In this article, the present knowledge on the methylation process is reviewed.
Downloads
References
Agrelo R, Cheng WH, Setien F, Ropero S, Espada J, Fraga M, Herranz M, Paz MF, Sanchez-Cespedes M, Artiga MJ, Guerrero D, Castells A, von Kobbe C, Bohr VA, Esteller M, Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer., Proceedings of the National Academy of Sciences of the United States of America, USA 2006 June 6; 103(23): 8822–8827 DOI: https://doi.org/10.1073/pnas.0600645103
Azhikina TL, Sverdlov ED, Study of Tissue-Specific CpG Methylation of DNA in Extended Genomic Loci., Biochemistry (Moscow) 2005 May;70(5):596-603 DOI: https://doi.org/10.1007/s10541-005-0153-9
Bulkowska U, Charakterystyka szczepów drożdży Saccharomyces cerevisiae wyrażających mysie metylotransferazy DNA, Dnmt1 i Dnmt3a; strona internetowa: http://www.biol.uw.edu.pl/www/_php/index_base.php?Screen_Option=3&News_ID=122
Connor C, Akbarian S, DNA methylation changes in schizophrena and bipolar disorder., Epigenetics. 2008 Mar-Apr;3(2):55-58 DOI: https://doi.org/10.4161/epi.3.2.5938
Esteller M, Corn PG, Baylin SB, Herman JG, A gene hypermethylation profile of human cancer., Cancer Research 2001;61: 3225-3229 DOI: https://doi.org/10.1007/BF02979467
Hattman S, DNA-Adenine Methylation in lower Eucaryotes., Biochemistry (Moscow) 2005 May; 70 (5):550-558 DOI: https://doi.org/10.1007/s10541-005-0148-6
Hermann A, Schmitt S, Jeltsch A, The Human Dnmt2 Has Residual DNA-(Cytosine-C5) Methyltransferase Activity, The Journal of Biological Chemistry 2003 Aug 22; 278 (34): 31717-31721 DOI: https://doi.org/10.1074/jbc.M305448200
Jabłońska J, Jesionek-Kupnicka D, Zmiany epigentyczne w nowotworach., Onkologia Polska 2004; 7(4): 181-185
Kawasaki T, Ohnishi M, Suemoto Y, Kirkner GJ, Liu Z, Yamamoto H, Loda M, Fuchs CS, Ogino S, WRN promoter methylation possibly connects mucinous differentiation, microsatellite instability and CpG island methylator phenotype in colorectal cancer., Modern pathology : an official journal of the United States and Canadian Academy of Pathology 2008 Feb; 21(2): 150-158 DOI: https://doi.org/10.1038/modpathol.3800996
Meijer H, de Graaff E, Merckx DM, Jongbloed RJ, de Die-Smulders CE, Engelen JJ, Fryns JP, Curfs PM, Oostra BA, A deletion of 1.6 kb proximal to the CGG repeat of the FMR1 gene causes the clinical phenotype of the fragile X syndrome., Human Molecular Genetics 1994 Apr; 3(4):615-620 DOI: https://doi.org/10.1093/hmg/3.4.615
Mund C, Brueckner B, Lyko F, Reactivation of epigenetically Silenced Genes by DNA Methyltransferase Inhibitors., Epigenetics 2006 Jan- Mar ;1(1):7-13 DOI: https://doi.org/10.4161/epi.1.1.2375
Reik W, Dean W, Walter J, Epigenetic reprogramming in mammalian development., Science. Washington 2001 Aug 10; 293(5532): 1089-1094 DOI: https://doi.org/10.1126/science.1063443
Salnikow K, Zhitkovich A, Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic and chromium., Chemical Rresearch in Toxicology 2008 Jan; 21(1): 28-44 DOI: https://doi.org/10.1021/tx700198a
Salozhin SV, Prokhorchuk EB, Georgiev GP, Methylation of DNA-One of the major epigenetic markers., Biochemistry (Moscow) 2005 May;70(5):525-532 DOI: https://doi.org/10.1007/s10541-005-0146-8
Sikora W, Dziedziczenie epigenetyczne; strona internetowa: http://bioinfo.mol.uj.edu.pl/articles/Sikora05
Strachan T., Read A., Human Molecular Genetics 2, BIOS Scintific Publishers Ltd. 1999
Sulewska A, Niklinska W, Kozlowski M, Minarowski L et al, Detection of DNA methylation in eucaryotic cells., Folia Histochemica et Cytobiologica Bialystok 2007; 45 (4): 315-325
Sulewska A, Niklinska W, Kozlowski M, Minarowski L et al, DNA methylation in states of cell physiology and pathology., Folia Histochemica et Cytobiologica Bialystok 2007; 45(3): 149-159
Vanyushin BF, Enzymatic DNA Methylation Is an Epigenetic Control for Genetic Functions of the Cell., Biochemistry (Moscow) 2005; 70 (5): 488-598 DOI: https://doi.org/10.1007/s10541-005-0143-y
Volpe P, The language of methylation in genomics of Eucaryotes., Biochemistry (Moscow) 2005 May ;70 (5):584-595 DOI: https://doi.org/10.1007/s10541-005-0152-x
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
For all articles published in Prospects in Pharmaceutical Sciences copyright is retained by the authors. The journal publishes articles in the Open Access policy, within the CC BY 4.0 licence.
This is a human-readable summary of (and not a substitute for) the license. Disclaimer.
You are free to:
Share — copy and redistribute the material in any medium or format
Adapt — remix, transform, and build upon the material for any purpose, even commercially.
The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation.
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
How to Cite
