WPŁYW METYLACJI DNA NA FUNKCJONOWANIE GENOMU

Marcin Łukasik; Jolanta Karmalska; Mirosław M. Szutowski; Jacek Łukaszkiewicz

doi:10.56782/pps.62

Published : 2009-02-26

Vol. 7 No. 2 (2009)

EFFECT OF DNA METHYLATION ON GENOME FUNCTION

Marcin Łukasik

Jolanta Karmalska

Mirosław M. Szutowski

Jacek Łukaszkiewicz

DOI: https://doi.org/10.56782/pps.62

Abstract

In biochemistry, methylation refers to the replacement of a hydrogen atom with a methyl group. DNA methylation is a type of chemical modification of DNA that can be inherited and subsequently removed without changing the original DNA sequence. It has been demonstrated that DNA methylation is involved in a number of biological processes such as parental imprinting, X chromosome inactivation, and development of tumors. In this article, the present knowledge on the methylation process is reviewed.

Keywords:

DNA methylation, genome, imprinting

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Łukasik, M., Karmalska, J., Szutowski, M. M., & Łukaszkiewicz, J. (2009). EFFECT OF DNA METHYLATION ON GENOME FUNCTION. Prospects in Pharmaceutical Sciences, 7(2), 13–18. https://doi.org/10.56782/pps.62

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Marcin Łukasik

Affiliation:

Katedra i Zakład Toksykologii, Wydział Farmaceutyczny, Warszawski Uniwersytet Medyczny, Katedra i Zakład Toksykologii Poland

Jolanta Karmalska

Affiliation:

Katedra i Zakład Toksykologii, Wydział Farmaceutyczny, Warszawski Uniwersytet Medyczny, Katedra i Zakład Toksykologii Poland

Mirosław M. Szutowski

Affiliation:

Katedra i Zakład Toksykologii, Wydział Farmaceutyczny, Warszawski Uniwersytet Medyczny, Katedra i Zakład Toksykologii Poland

Jacek Łukaszkiewicz

Affiliation:

Katedra i Zakład Biochemii i Chemii Klinicznej, Wydział Farmaceutyczny, Warszawski Uniwersytet Medyczny Poland