WPŁYW METYLACJI DNA NA FUNKCJONOWANIE GENOMU

Marcin Łukasik; Jolanta Karmalska; Mirosław M. Szutowski; Jacek Łukaszkiewicz

doi:10.56782/pps.62

Published : 2009-02-26

Vol. 7 No. 2 (2009)

EFFECT OF DNA METHYLATION ON GENOME FUNCTION

Marcin Łukasik

Jolanta Karmalska

Mirosław M. Szutowski

Jacek Łukaszkiewicz

DOI: https://doi.org/10.56782/pps.62

Abstract

In biochemistry, methylation refers to the replacement of a hydrogen atom with a methyl group. DNA methylation is a type of chemical modification of DNA that can be inherited and subsequently removed without changing the original DNA sequence. It has been demonstrated that DNA methylation is involved in a number of biological processes such as parental imprinting, X chromosome inactivation, and development of tumors. In this article, the present knowledge on the methylation process is reviewed.

Keywords:

DNA methylation, genome, imprinting

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Łukasik, M., Karmalska, J., Szutowski, M. M., & Łukaszkiewicz, J. (2009). EFFECT OF DNA METHYLATION ON GENOME FUNCTION. Prospects in Pharmaceutical Sciences, 7(2), 13–18. https://doi.org/10.56782/pps.62

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References

Agrelo R, Cheng WH, Setien F, Ropero S, Espada J, Fraga M, Herranz M, Paz MF, Sanchez-Cespedes M, Artiga MJ, Guerrero D, Castells A, von Kobbe C, Bohr VA, Esteller M, Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer., Proceedings of the National Academy of Sciences of the United States of America, USA 2006 June 6; 103(23): 8822–8827 DOI: https://doi.org/10.1073/pnas.0600645103

Azhikina TL, Sverdlov ED, Study of Tissue-Specific CpG Methylation of DNA in Extended Genomic Loci., Biochemistry (Moscow) 2005 May;70(5):596-603 DOI: https://doi.org/10.1007/s10541-005-0153-9

Bulkowska U, Charakterystyka szczepów drożdży Saccharomyces cerevisiae wyrażających mysie metylotransferazy DNA, Dnmt1 i Dnmt3a; strona internetowa: http://www.biol.uw.edu.pl/www/_php/index_base.php?Screen_Option=3&News_ID=122

Connor C, Akbarian S, DNA methylation changes in schizophrena and bipolar disorder., Epigenetics. 2008 Mar-Apr;3(2):55-58 DOI: https://doi.org/10.4161/epi.3.2.5938

Esteller M, Corn PG, Baylin SB, Herman JG, A gene hypermethylation profile of human cancer., Cancer Research 2001;61: 3225-3229 DOI: https://doi.org/10.1007/BF02979467

Hattman S, DNA-Adenine Methylation in lower Eucaryotes., Biochemistry (Moscow) 2005 May; 70 (5):550-558 DOI: https://doi.org/10.1007/s10541-005-0148-6

Hermann A, Schmitt S, Jeltsch A, The Human Dnmt2 Has Residual DNA-(Cytosine-C5) Methyltransferase Activity, The Journal of Biological Chemistry 2003 Aug 22; 278 (34): 31717-31721 DOI: https://doi.org/10.1074/jbc.M305448200

Jabłońska J, Jesionek-Kupnicka D, Zmiany epigentyczne w nowotworach., Onkologia Polska 2004; 7(4): 181-185

Kawasaki T, Ohnishi M, Suemoto Y, Kirkner GJ, Liu Z, Yamamoto H, Loda M, Fuchs CS, Ogino S, WRN promoter methylation possibly connects mucinous differentiation, microsatellite instability and CpG island methylator phenotype in colorectal cancer., Modern pathology : an official journal of the United States and Canadian Academy of Pathology 2008 Feb; 21(2): 150-158 DOI: https://doi.org/10.1038/modpathol.3800996

Meijer H, de Graaff E, Merckx DM, Jongbloed RJ, de Die-Smulders CE, Engelen JJ, Fryns JP, Curfs PM, Oostra BA, A deletion of 1.6 kb proximal to the CGG repeat of the FMR1 gene causes the clinical phenotype of the fragile X syndrome., Human Molecular Genetics 1994 Apr; 3(4):615-620 DOI: https://doi.org/10.1093/hmg/3.4.615

Mund C, Brueckner B, Lyko F, Reactivation of epigenetically Silenced Genes by DNA Methyltransferase Inhibitors., Epigenetics 2006 Jan- Mar ;1(1):7-13 DOI: https://doi.org/10.4161/epi.1.1.2375

Reik W, Dean W, Walter J, Epigenetic reprogramming in mammalian development., Science. Washington 2001 Aug 10; 293(5532): 1089-1094 DOI: https://doi.org/10.1126/science.1063443

Salnikow K, Zhitkovich A, Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic and chromium., Chemical Rresearch in Toxicology 2008 Jan; 21(1): 28-44 DOI: https://doi.org/10.1021/tx700198a

Salozhin SV, Prokhorchuk EB, Georgiev GP, Methylation of DNA-One of the major epigenetic markers., Biochemistry (Moscow) 2005 May;70(5):525-532 DOI: https://doi.org/10.1007/s10541-005-0146-8

Sikora W, Dziedziczenie epigenetyczne; strona internetowa: http://bioinfo.mol.uj.edu.pl/articles/Sikora05

Strachan T., Read A., Human Molecular Genetics 2, BIOS Scintific Publishers Ltd. 1999

Sulewska A, Niklinska W, Kozlowski M, Minarowski L et al, Detection of DNA methylation in eucaryotic cells., Folia Histochemica et Cytobiologica Bialystok 2007; 45 (4): 315-325

Sulewska A, Niklinska W, Kozlowski M, Minarowski L et al, DNA methylation in states of cell physiology and pathology., Folia Histochemica et Cytobiologica Bialystok 2007; 45(3): 149-159

Vanyushin BF, Enzymatic DNA Methylation Is an Epigenetic Control for Genetic Functions of the Cell., Biochemistry (Moscow) 2005; 70 (5): 488-598 DOI: https://doi.org/10.1007/s10541-005-0143-y

Volpe P, The language of methylation in genomics of Eucaryotes., Biochemistry (Moscow) 2005 May ;70 (5):584-595 DOI: https://doi.org/10.1007/s10541-005-0152-x

Marcin Łukasik

Affiliation:

Katedra i Zakład Toksykologii, Wydział Farmaceutyczny, Warszawski Uniwersytet Medyczny, Katedra i Zakład Toksykologii Poland

Jolanta Karmalska

Affiliation:

Katedra i Zakład Toksykologii, Wydział Farmaceutyczny, Warszawski Uniwersytet Medyczny, Katedra i Zakład Toksykologii Poland

Mirosław M. Szutowski

Affiliation:

Katedra i Zakład Toksykologii, Wydział Farmaceutyczny, Warszawski Uniwersytet Medyczny, Katedra i Zakład Toksykologii Poland

Jacek Łukaszkiewicz

Affiliation:

Katedra i Zakład Biochemii i Chemii Klinicznej, Wydział Farmaceutyczny, Warszawski Uniwersytet Medyczny Poland