1. Menon, G.K.; Kligman, A.M. Barrier functions of human skin: a holistic view. Skin Pharmacol. Physiol. 2009, 22(4), 178-189. DOI: 10.1159/000231523
2. Piipponen, M.; Li, D.; Landén, N.X. The immune functions of keratinocytes in skin wound healing. Int. J. Mol. Sci. 2020, 21(22), Art. No: 8790. DOI: 10.3390/ijms21228790
3. Rashid, A.; Akram, M.; Kayode, O.T.; Kayode, A.A. Clinical features and epidemiological patterns of infections by multidrug resistance Staphylococcus aureus and Pseudomonas aeruginosa in patients with burns. Biomed. J. Sci. Tech. Res. 2020, 25(4), 19272-19278. DOI: 10.26717/BJSTR.2020.25.004222
4. Brunel, A.S.; Guery, B. Multidrug resistant (or antimicrobial-resistant) pathogens-alternatives to new antibiotics? Swiss Med. Wkly 2017, 147, Art. No: w14553. DOI: 10.4414/smw.2017.14553
5. El-Saadony, M.T.; Saad, A.M.; Mohammed, D.M.; Korma, S.A.; Alshahrani, M.Y.; Ahmed, A.E.; Ibrahim, E.H.; Salem, H.M.; Alkafaas, S.S.; Saif, A.M.; Elkafas, S.S. Medicinal plants: bioactive compounds, biological activities, combating multidrug-resistant microorganisms, and human health benefits – a comprehensive review. Front. Immunol. 2025, 16, Art. No: 1491777. DOI: 10.3389/fimmu.2025.1491777
6. Rosique, R.G.; Rosique, M.J.; Farina Junior, J.A. Curbing inflammation in skin wound healing: a review. Int. J. Inflamm. 2015, 2015(1), Art. No: 316235. DOI: 10.1111/j.1742-4801.2006.00212.x
7. Feliciani, C.; Gupta, A.K.; Saucier, D.N. Keratinocytes and cytokine/growth factors. Crit. Rev. Oral Biol. Med. 1996, 7(4), 300-318. DOI: 10.1177/10454411960070040101
8. Jiratchayamaethasakul, C.; Ding, Y.; Hwang, O.; Im, S.T.; Jang, Y.; Myung, S.W.; Lee, J.M.; Kim, H.S.; Ko, S.C.; Lee, S.H. In vitro screening of elastase, collagenase, hyaluronidase, and tyrosinase inhibitory and antioxidant activities of 22 halophyte plant extracts for novel cosmeceuticals. Fish. Aquat. Sci. 2020, 23(1), Art. No: 6. DOI: 0.1186/s41240-020-00149-8
9. Tsioutsiou, E.E.; Amountzias, V.; Vontzalidou, A.; Dina, E.; Stevanović, Z.D.; Cheilari, A.; Aligiannis, N. Medicinal plants used traditionally for skin related problems in the south Balkan and east Mediterranean region—a review. Front. Pharmacol. 2022, 13, Art. No: 936047. DOI: 10.3389/fphar.2022.936047
10. Dogara, A.M.; Lema, A.A.; Hama, H.A.; Hamad, S.W.; Mahmod, N.H.; Khandaker, M.M.; Amlabu, W.E. Ethnopharmacology, biological evaluation and chemical composition of Boswellia dalzielii hutch: A review. Indones. J. Pharm. 2023, 33(4), 515 – 539.
11. Olukemi, M.A.; Kandakai-Olukemi, Y.T.; Mawak, J.D. Antibacterial activity of the stem bark of Boswellia dalzielii. J. Pharm. Bioresour. 2005, 2(2), 131-136.
12. Otitoju, A.P.; Longdet, I.Y.; Alemika, T.E.; Adegoke, A.M.; Gota, V.P. Cytotoxic activity of Boswellia dalzielii (Hutch) stem bark extract against head and neck squamous cell carcinoma of the tongue (AW8507 cell line). J. Pharm. Bioresour. 2019, 16(2), 187-194. DOI: 10.1186/s43046-021-00075-3
13. DeCarlo, A.; Dosoky, N.S.; Satyal, P.; Sorensen, A.; Setzer, W.N. The essential oils of the Burseraceae. In Essential Oil Research: Trends in Biosynthesis, Analytics, Industrial Applications and Biotechnological Production. 2019, pp. 61-145. Cham: Springer International Publishing.
14. Kubmarawa, D.; Ogunwande, I.A.; Okorie, D.A.; Olawore, N.O.; Kasali; A.A. Constituents of the essential oils of Boswellia dalzielii Hutch. Nigeria. J. Essent. Oil Res. 2006, 18, 119-120. DOI: 10.1080/10412905.2006.9699038
15. Mamza, U.T.; Sodipo, O.A.; Abdulrahman, F.I.; Khan, I.Z. Phytochemical analysis and in vitro antimicrobial assay of the methanolic stem bark extract of Boswellia dalzielii Hutch (Burseraceae). J. Chem. Res. 2018, 3, 161-168.
16. Abdulhamid, A.; Sani, I. Phytochemical Screening and In-Vitro Antibacterial Potential of Boswellia dalzielii (Hutch.) Stem Bark Extracts. East African Scholars J. Med. Sci. 2019, 2, 213-217.
17. Abubakar, U.S.; Yusuf, K.M.; Abdu, G.T.; Saidu, S.R.; Jamila, G.A.; Fatima, A. Ethnopharmacological survey of medicinal plants used for the management of pediatric ailments in Kano State, Nigeria. Res. J. Pharmacogn. 2017, 4(3), 29-39.
18. Ohemu, T.L.; Agunu, A.; Olotu, P.N.; Ajima, U.; Dafam, D.G.; Azila, J.J. Ethnobotanical survey of medicinal plants used in the traditional treatment of viral infections in Jos, Plateau state, Nigeria. Int. J. Med. Arom. Plants. 2014, 4, 74-81.
19. Alemika, T.E.; Onawunmi, G.O.; Olugbade, T.A. Isolation and characterization of incensole from Boswellia dalzielii stem bark. J. Pharm. Bioresour. 2004, 1(1), 7-11.
20. Kafuti, Y.S.; Ojerinde, S.O.; Balogun, O.; Alemika, T.E.; Taba, K.M.; Mpiana, P.T.; Kindombe, N.M. Antifungal evaluation and phytochemical screening of methanolic extract and fractions of Boswellia dalzielii stem bark. J. Pharm. Bioresour. 2017, 14(1), 62-67.
21. Mbiantcha, M.; Almas, J.; Atsamo, A.D.; Ateufack, G.; Shabana, S.U.; Bomba Tatsinkou, D.F.; Yousseu Nana, W.; Nida, D. Anti-inflammatory and anti-arthritic effects of methanol extract of the stem bark of Boswellia dalzielii hutch (Burseraceae) in rats. Inflammopharmacology 2018, 26(6), 1383-1398. DOI: 10.1007/s10787-018-0505-x
22. Nazifi, A.B.; Danjuma, N.M.; Olurishe, T.O.; Ya’u, J. Behavioural effects of methanol stem bark extract of Boswellia dalzielii Hutch (Burseraceae) in mice. Afr. J. Biomed. Res. 2017, 20(1), 103-108.
23. Salihu, T.; Olukunle, J.O.; Adenubi, O.T.; Mbaoji, C.; Zarma, M.H. Ethnomedicinal plant species commonly used to manage arthritis in North-West Nigeria. S. Afr. J. Bot. 2018, 118, 33-43. DOI: 10.1016/j.sajb.2018.06.004
24. Akomolafe, S. F.; Fabjanowicz, M.; Granica; S. Comprehensive analysis of antioxidant activity and phytochemical profile of leaf, stem bark, and root bark aqueous extracts of Boswellia dalzielii Hutch: an in vitro and UHPLC-DAD-MS studies. Acta Soc. Bot. Pol. 2025, 94, Art. No: 212105. DOI: 10.5586/asbp/212105
25. Ohemu, T.; Okwori, V.; Dafam, D.; Kagaru, D.; Yakubu, T.; Usman, Y. Pharmacognostic and proximate evaluations of the leaves, stem bark and roots of Boswellia dalzielii Hutch (Burseraceae). Nig. J. Prod. Med. 2018, 22, 115-123. DOI: 10.4314/njnpm.v22i1.4
26. Ndlovu, G.; Fouche, G.; Tselanyane, M.; Cordier, W.; Steenkamp, V. In vitro determination of the anti-aging potential of four southern African medicinal plants. BMC Complement. Altern. Med. 2013, 13(1), Art. No: 304. DOI: 10.1111/j.1365-4362.1996.tb03650.x
27. Jakupović, L.; Bačić, I.; Jablan, J.; Marguí, E.; Marijan, M.; Inić, S.; Nižić Nodilo, L.; Hafner, A.; Zovko Končić, M. Hydroxypropyl-β-Cyclodextrin-Based Helichrysum italicum extracts: antioxidant and cosmeceutical activity and biocompatibility. Antioxidants 2023, 12, Art. No: 855. DOI: 10.3390/antiox12040855
28. Van Wart, H.E.; Steinbrink, D.R. A continuous spectrophotometric assay for Clostridium histolyticum collagenase. Anal. Biochem. 1981, 113(2), 356-365. DOI: 10.1016/0003-2697(81)90089-0
29. Ghuman, S.; Ncube, B.; Finnie, J.F.; McGaw, L.J.; Coopoosamy, R.M.; Van Staden, J. Antimicrobial activity, phenolic content, and cytotoxicity of medicinal plant extracts used for treating dermatological diseases and wound healing in KwaZulu-Natal, South Africa. Front. Pharmacol. 2016, 7, Art. No: 320. DOI: 10.3389/fphar.2016.00320
30. Kohoude, M.J.; Gbaguidi, F.; Agbani, P.; Ayedoun, M.A.; Cazaux, S.; Bouajila, J. Chemical composition and biological activities of extracts and essential oil of Boswellia dalzielii leaves. Pharm. Biol. 2017, 55(1), 33-42. DOI: 10.1080/13880209.2016.1226356
31. Ahmed, H.H.; Abd-Rabou, A.A.; Hassan, A.Z.; Kotob, S.E. Phytochemical analysis and anti-cancer investigation of Boswellia serrata bioactive constituents in vitro. Asian Pac. J. Cancer Prev. 2015, 16(16), 7179-7188. DOI: 10.7314/apjcp.2015.16.16.7179
32. Majeed, M.; Nagabhushanam, K.; Lawrence, L.; Nallathambi, R.; Thiyagarajan, V.; Mundkur, L. Boswellia serrata extract containing 30% 3-acetyl-11-keto-boswellic acid attenuates inflammatory mediators and preserves extracellular matrix in collagen-induced arthritis. Front. Physiol. 2021, 12, Art. No: 735247. DOI: 10.3389/fphys.2021.735247
33. Bártolo, I.; Reis, R.L.; Marques, A.P.; Cerqueira, M.T. Keratinocyte growth factor-based strategies for wound re-epithelialization. Tissue Eng. Part B Rev. 2022, 28(3), 665-676. DOI: 10.1089/ten.teb.2021.0030
34. Schilrreff, P.; Alexiev, U. Chronic inflammation in non-healing skin wounds and promising natural bioactive compounds treatment. Int. J. Mol. Sci. 2022, 23(9), Art. No: 4928. DOI: 10.3390/ijms23094928
35. Alqarni, A. Evaluation of the antibacterial, anti-inflammatory and wound healing properties of frankincense (Boswellia frereana) 2025, (Doctoral dissertation, Cardiff University).
36. Shedoeva, A.; Leavesley, D.; Upton, Z.; Fan, C. Wound healing and the use of medicinal plants. eCAM 2019, 2019(1), Art. No: 2684108. DOI: 10.1155/2019/2684108
37. Anzar, C.A.; Joseph, M.V.; Sundaram, R.; Vadiraj, G.B.; Prasad, C.P.; Eranimose, B. A novel therapeutic effect of the wound healing activity of Boswellia serrata extract (boswegex®) by using the human dermal fibroblast (HDF) cell line: an in-vitro study. Int. J. Pharm. Sci. Res. 2024, 15, 756-762. DOI: 10.13040/IJPSR.0975-8232.15(3).756-62
38. Jiang, Y.; Tsoi, L.C.; Billi, A.C.; Ward, N.L.; Harms, P.W.; Zeng, C.; Maverakis, E.; Kahlenberg, J.M.; Gudjonsson, J.E. Cytokinocytes: the diverse contribution of keratinocytes to immune responses in skin. JCI Insight 2020, 5(20), Art. No: e142067. DOI: 10.1172/jci.insight.142067
39. Ammon, H.P.T. Boswellic acids and their role in chronic inflammatory diseases. Adv. Exp. Med. Biol. 2016, 928, 291-327. DOI: 10.1007/978-3-319-41334-1_13
40. T sai, Y.C.; Chang, H.H.; Chou, S.C.; Chu, T.W.; Hsu, Y.J.; Hsiao, C.Y.; Lo, Y.H.; Wu, N.L.; Chang, D.C.; Hung, C.F. Evaluation of the anti-atopic dermatitis effects of α-boswellic acid on Tnf-α/Ifn-γ-Stimulated HaCat Cells and DNCB-Induced BALB/c Mice. Int. J. Mol. Sci. 2022, 23(17), Art. No: 9863. DOI: 10.3390/ijms23179863
41. Hamadjida, A.; Mbomo, R.E.A.; Minko, S.E.; Ntchapda, F.; Mingoas, J.P.K.; Nnanga, N. Antioxidant and anti-inflammatory effects of Boswellia dalzielii and Hibiscus sabdariffa extracts in alloxan-induced diabetic rats. Metabol. Open 2024, 21, Art. No: 100278. DOI: 10.1016/j.metop.2024.100278
42. Medzhitov, R. Origin and physiological roles of inflammation. Nature 2008, 454(7203), 428-435. DOI: 10.1038/nature07201
43. Xie, Q.W.; Nathan, C. The high-output nitric oxide pathway: role and regulation. J. Leukoc. Biol. 1994, 56(5), 576-582. DOI: 10.1002/jlb.56.5.576
44. Bogdan, C. Nitric oxide and the immune response. Nat. Immunol. 2001, 2(10), 907-916. DOI: 10.1038/ni1001-907
45. Kannan, G.; Paul, B.M.; Thangaraj, P. Stimulation, regulation, and inflammaging interventions of natural compounds on nuclear factor kappa B (NF-kB) pathway: a comprehensive review. Inflammopharmacology 2025, 33(1), 145-162. DOI: 10.1007/s10787-024-01635-4
46. Al-Khayri, J.M.; Mascarenhas, R.; Harish, H.M.; Gowda, Y.; Lakshmaiah, V.V.; Nagella, P.; Al-Mssallem, M.Q.; Alessa, F.M.; Almaghasla, M.I.; Rezk, A.A.S. Stilbenes, a versatile class of natural metabolites for inflammation—an overview. Molecules 2023, 28(9), Art. No: 3786. DOI: 10.3390/molecules28093786
47. Koh, Y.C.; Ho, C.T.; Pan, M.H. Recent advances in health benefits of stilbenoids. J. Agric. Food Chem. 2021, 69(35), 10036-10057. DOI: 10.1021/acs.jafc.1c03699
48. Ammon, H.P.T. Modulation of the immune system by Boswellia serrata extracts and boswellic acids. Phytomedicine 2010, 17(11), 862-867. DOI: 10.1016/j.phymed.2010.03.003
49. Sharma, A.; Bhatia, S.; Kharya, M.D.; Gajbhiye, V.; Ganesh, N.; Namdeo, A.G.; Mahadik, K.R. Anti-inflammatory and analgesic activity of different fractions of Boswellia serrata. Int. J. Phytomed. 2010, 2(1), 94-99. DOI: 10.5138/ijpm.2010.0975.0185.02015
50. Safayhi, H.; Rall, B.; Sailer, E.R.; Ammon, H.P. Inhibition by boswellic acids of human leukocyte elastase. J. Pharmacol. Exp. Ther. 1997, 281(1), 460-463. DOI: 10.1016/S0022-3565(24)36628-5
51. Siemoneit, U.; Koeberle, A.; Rossi, A.; Dehm, F.; Verhoff, M.; Reckel, S.; Maier, T.J.; Jauch, J.; Northoff, H.; Bernhard, F.; Doetsch, V. Inhibition of microsomal prostaglandin E2 synthase‐1 as a molecular basis for the anti‐inflammatory actions of boswellic acids from frankincense. Br. J. Pharmacol. 2011, 162(1), 147-162. DOI: 10.1111/j.1476-5381.2010.01020.x
52. Ammon, H.P.T. Boswellic acids in chronic inflammatory diseases. Planta Med. 2006, 72(12), 1100-1116. DOI: 10.1055/s-2006-947227
53. Efron, D.T.; Most, D.; Barbul, A. Role of nitric oxide in wound healing. Curr. Opin. Clin. Nutr. Metab. Care. 2000, 3(3), 197-204. DOI: 10.1177/1099800402004001002
54. Potekaev, N.N.; Borzykh, O.B.; Medvedev, G.V.; Pushkin, D.V.; Petrova, M.M.; Petrov, A.V.; Dmitrenko, D.V.; Karpova, E.I.; Demina, O.M.; Shnayder, N.A. The role of extracellular matrix in skin wound healing. J. Clin. Med. 2021, 10(24), Art. No: 5947. DOI: 10.1007/s00403-009-1014-y
55. Ashruf, O.S.; Ansari, M.Y. Natural compounds: potential therapeutics for the inhibition of cartilage matrix degradation in osteoarthritis. Life 2022, 13(1), Art. No: 102. DOI: 10.3390/life13010102
56. Biswas, P.C.; Saroj, B.K.; Raju, S.K.; Konda,VVS K.; Mukherjee, R.K.; P, N.; Jilani, A.K.; Jilani, A.K.; Kx, S. Antioxidant And Anti-Inflammatory Activities Of Boswellia Serrata Leaf Extract: A Pharmacological Perspective. Rev. Electron. Vet. 2024, 25(1), 1451 -1460. DOI: 10.69980/redvet.v25i1.925
57. Ratnam, K.V.; Bhakshu, L.M. Traditional uses and pharmacology of Boswellia species. In Frankincense–Gum Olibanum 2023, pp. 151-214. Apple Academic Press. DOI: 10.1201/9781003348016-7
58. Umar, S.; Umar, K.; Sarwar, A.H.M.G.; Khan, A.; Ahmad, N.; Ahmad, S.; Katiyar, C.K.; Husain, S.A.; Khan, H.A. Boswellia serrata extract attenuates inflammatory mediators and oxidative stress in collagen induced arthritis. Phytomedicine 2014, 21(6), 847-856. DOI: 10.1016/j.phymed.2014.03.001
59. Lee, K.K.; Cho, J.J.; Park, E.J.; Choi, J.D. Anti‐elastase and anti‐hyaluronidase of phenolic substance from Areca catechu as a new anti‐ageing agent. Int. J. Cosmet. Sci. 2001, 23(6), 341-346. DOI: 10.1046/j.0412-5463.2001.00102.x
60. Vestweber, P.K.; Wächter, J.; Planz, V.; Jung, N.; Windbergs, M. The interplay of Pseudomonas aeruginosa and Staphylococcus aureus in dual-species biofilms impacts development, antibiotic resistance and virulence of biofilms in in vitro wound infection models. PLOS One 2024, 19(5), Art. No: e0304491. DOI: 10.1371/journal.pone.0304491
61. Todorović, P.; Krstić Ristivojević, M.; Jović, M.; Ivković, Đ.; Nestorović Živković, J.; Gašić, U.; Dimkić, I.; Stojiljković, I.; Ristivojević, P. Antimicrobial Effect of Boswellia serrata Resin’s Methanolic Extracts Against Skin Infection Pathogens. Processes 2025, 13(3), Art. No: 850. DOI: 10.3390/pr13030850
62. Hasson, S.S.; Al-Balushi, M.S.; Sallam, T.A.; Idris, M.A.; Habbal, O.; Al-Jabri, A.A. In vitro antibacterial activity of three medicinal plants-Boswellia (Luban) species. Asian Pac. J. Trop. Biomed. 2011, 1(2), S178-S182. DOI: 10.13005/bbra/2570
63. Salisu, B.U.; Muhammad, A.M.; Mohammed, A.H.; Adamu, U. Determination of phytochemicals and antimicrobial activity of aqueous stem bark extract of Boswellia dalzielii against some common pathogenic microorganisms. UJMR 2017, 2(1), 238-246.
64. El-sayed, N.R.; Samir, R.; Jamil M. Abdel-Hafez, L.; Ramadan, M.A. Olive leaf extract modulates quorum sensing genes and biofilm formation in multi-drug resistant Pseudomonas aeruginosa. Antibiotics 2020, 9(9), Art. No: 526. DOI: 10.3390/antibiotics9090526
65. Piegerová, A.; Koščová, J.; Schusterová, P.; Nemcová, R.; Kryvtsova, M. In vitro inhibition of biofilm formation by Staphylococcus aureus under the action of selected plant extracts. Folia Vet. 2019, 63, 48–53. DOI: 10.2478/fv-2019-0007
66. Tegasne, C.; Kapche, G.D.W.F.; Mawabo, I.K.; Talla, R.M.; Jouda, J.B.; Happi, G.M.; Lenta, B.N.; Frese, M.; Abegaz, B.M.; Sewald, N. Bioguided chemical study of Boswellia dalzielii Hutch. (Burseraceae) for antibacterial agents and a new glucopyranoxylmethoxybenzyle. Nat. Prod. Res. 2021, 35(23), 5199-520. DOI: 10.1080/14786419.2020.1794863