PHOTOSENSITIVITY PHENOMENON – A SIGNIFICANT ADVERSE EFFECT OF COMMONLY USED DRUGS
DOI:
https://doi.org/10.56782/pps.8Keywords:
drug-induced photosensitivity, phototoxicity, photoallergyAbstract
Drug-induced photosensitivity is an adverse effect of topically or systemically administered therapeutic substances caused by exposure to UVA, UVB, and visible light. It accounts for 8% of skin reactions to medications. It may occur as an effect of phototoxicity, when photoactivation of a drug or its metabolite in the skin results in the formation of a photoproduct or reactive oxygen species (ROS) or be a consequence of photoallergy – delayed type IV hypersensitivity reaction to the photoproduct. The occurrence of these phenomena depends on the structure of the molecule and physical and chemical properties of a xenobiotic. Many drugs have the potential to cause photosensitivity, including antimicrobial medications (doxycycline, tetracycline, isoniazid), antifungal drugs (voriconazole), non-steroidal anti-inflammatory drugs (naproxen, ketoprofen, piroxicam), medicines used in cardiovascular diseases (amiodarone, hydrochlorothiazide), antipsychotics (chlorpromazine, thioridazine), furanocoumarins (psoralen derivatives) as well as plant substances such as St. John's wort. Diagnosis of photosensitivity is based on a phototest. Prevention of phototoxicity and photoallergy includes avoiding sun exposure and the use of sunscreens, while treatment focuses on symptoms’ alleviation and administration of anti-inflammatory drugs in the case of photoallergy.
Downloads
References
International Organization for Standardization, Definitions of Solar Irradiance Spectral Categories (Standard nr 21348), 2007, Internet: https://www.iso.org/standard/39911.html (dostęp 23.04.2021).
Chantorn, R., Lim, H. W., Shwayder, T. A., Photosensitivity disorders in children: part I, Journal of the American Academy of Dermatology, 2012, 67(6): 1093: 1-18. DOI: https://doi.org/10.1016/j.jaad.2012.07.033
Ray, R. S., Haldar, C., Dwivedi, A., Agarwal, N., Singh, J., Photocarcinogenesis & Photoprotection, Springer, Singapore, 2018, 77-84. DOI: https://doi.org/10.1007/978-981-10-5493-8
Elkeeb, D., Elkeeb, L., Maibach, H., Photosensitivity: a current biological overview, Cutaneous and Ocular Toxicology, 2012, 31(4): 263-272. DOI: https://doi.org/10.3109/15569527.2012.656293
Moore, D. E., Drug-induced cutaneous photosensitivity, Drug Safety, 2002, 25(5): 345-372. DOI: https://doi.org/10.2165/00002018-200225050-00004
Lugović-Mihić, L., Duvančić, T., Ferček, I., Vuković, P., Japundžić, I., Ćesić, D., Drug-induced photosensitivity-a continuing diagnostic challenge, Acta Clinica Croatica, 2017, 56(2): 277-283. DOI: https://doi.org/10.20471/acc.2017.56.02.11
Goetze, S., Hiernickel, C., Elsner, P., Phototoxicity of doxycycline: A systematic review on clinical manifestations, frequency, cofactors, and prevention, Skin Pharmacology and Physiology, 2017, 30: 76–80. DOI: https://doi.org/10.1159/000458761
Monteiro, A.F., Rato, M., Martins, C., Drug-induced photosensitivity: Photoallergic and phototoxic reactions, Clinical Dermatology, 2016, 34: 571–581. DOI: https://doi.org/10.1016/j.clindermatol.2016.05.006
Schmidt, F., Wenzel, J., Halland, N., Güssregen, S., Delafoy, L., Czich, A., Computational investigation of drug phototoxicity: photosafety assessment, photo-toxophore identification, and machine learning, Chemical Research in Toxicology, 2019, 32(11): 2338-2352. DOI: https://doi.org/10.1021/acs.chemrestox.9b00338
Bogumiła Zuba, E., Koronowska, S., Osmola-Mańkowska, A., Jenerowicz, D., Drug-induced photosensitivity, Acta Dermatovenerologica Croatica, 2016, 24(1): 55-64.
Katsambas, A. D., Lotti, T. M., Dessinioti, C., D'Erme, A. M., European handbook of dermatological treatments, Springer, Berlin, Germany, 2015, 233-252. DOI: https://doi.org/10.1007/978-3-662-45139-7
R. Mang, H. Stege, J. Krutmann, Mechanisms of phototoxic and photoallergic reactions, w: Johansen J.D., Frosch J.P., Lepoittevin J.P, Contact Dermatitis, Springer, Berlin, Heidelberg, 2011, 155–163. DOI: https://doi.org/10.1007/978-3-642-03827-3_8
Khandpur S., Porter R.M., Boulton S.J., Anstey A., Drug-induced photosensitivity: new insights into pathomechanisms and clinical variation through basic and applied science, British Journal of Dermatology, 2017, 176: 902–909. DOI: https://doi.org/10.1111/bjd.14935
Kim, W. B., Shelley, A. J., Novice, K., Joo, J., Lim, H. W., Glassman, S. J., Drug-induced phototoxicity: a systematic review, Journal of the American Academy of Dermatology, 2018, 79(6): 1069-1075. DOI: https://doi.org/10.1016/j.jaad.2018.06.061
Petković, H., Lukežič, T., Šušković, J. Biosynthesis of oxytetracycline by Streptomyces rimosus: past, present and future directions in the development of tetracycline antibiotics, Food technology and biotechnology, 2017, 55(1): 3-13. DOI: https://doi.org/10.17113/ftb.55.01.17.4617
Hall, J. C., Hall, B. J., Cutaneous drug eruptions: diagnosis, histopathology and therapy, Springer, London, 2015, 107-121. DOI: https://doi.org/10.1007/978-1-4471-6729-7
Blakely, K. M., Drucker, A. M., Rosen, C. F., Drug-induced photosensitivity – an update: Culprit drugs, prevention and management, Drug Safety, 2019, 42(7): 827-847. DOI: https://doi.org/10.1007/s40264-019-00806-5
Elmas, Ö. F., Akdeniz, N., A case of doxycyclin-induced photoonycholysis with dermoscopic features, Balkan Medical Journal, 2020, 37(2): 113. DOI: https://doi.org/10.4274/balkanmedj.galenos.2019.2019.11.22
McCarthy, S., Bourke, J. F. Image gallery: minocycline-induced photo-onycholysis with pigmentation, British Journal of Dermatology, 2019, 180(4): 102. DOI: https://doi.org/10.1111/bjd.17417
Wlodek, C., Narayan, S., A reminder about photo-onycholysis induced by tetracycline, and the first report of a case induced by lymecycline, Clinical and Experimental Dermatology, 2014, 6(39): 746-747. DOI: https://doi.org/10.1111/ced.12350
Drucker, A. M., Rosen, C. F., Drug-induced photosensitivity, Drug Safety, 2011, 34(10): 821-837. DOI: https://doi.org/10.2165/11592780-000000000-00000
Domagala, J. M., Structure-activity and structure-side-effect relationships for the quinolone antibacterials, Journal of Antimicrobial Chemotherapy, 1994, 33(4): 685-706. DOI: https://doi.org/10.1093/jac/33.4.685
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
For all articles published in Prospects in Pharmaceutical Sciences copyright is retained by the authors. The journal publishes articles in the Open Access policy, within the CC BY 4.0 licence.
This is a human-readable summary of (and not a substitute for) the license. Disclaimer.
You are free to:
Share — copy and redistribute the material in any medium or format
Adapt — remix, transform, and build upon the material for any purpose, even commercially.
The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation.
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
How to Cite
