Humulus species: a traditional medicinal plant and its modern pharmacological importance

Ghadir A. El-Chaghaby; Emre Sevindik; Mustafa Sevindik; Oguzhan Koçer; Imran Uysal

doi:10.56782/pps.388

Published : 2025-08-06

Vol. 23 No. 4 (2025)

Humulus species: a traditional medicinal plant and its modern pharmacological importance

Ghadir A. El-Chaghaby

Emre Sevindik

Mustafa Sevindik

Oguzhan Koçer

Imran Uysal

DOI: https://doi.org/10.56782/pps.388

Abstract

The genus Humulus, particularly Humulus lupulus (hops), has been widely recognized for its historical and traditional uses in various cultures due to its diverse biological activities. This review compiles the general characteristics, traditional uses, essential oil compositions, and pharmacological properties of Humulus species, with a focus on their antioxidant, antimicrobial, anti-inflammatory, anticancer, antiviral, and insecticidal activities. The essential oils of Humulus species, rich in bioactive compounds such as β-caryophyllene, α-humulene, and β-myrcene, contribute to their broad-spectrum therapeutic effects. These compounds have demonstrated significant potential in reducing oxidative stress, combating microbial infections, alleviating inflammation, and exhibiting cytotoxic effects against cancer cells. Additionally, the traditional uses of Humulus species for sleep regulation, digestive health, and hormone balance are supported by modern pharmacological studies. The antioxidant and antimicrobial properties of Humulus species highlight their potential as natural sources of antioxidants and alternatives to synthetic antibiotics, particularly in the face of rising antibiotic resistance. Furthermore, the insecticidal and allelopathic effects of these plants suggest their applicability in sustainable agriculture as eco-friendly biopesticides and weed control agents. Despite the promising findings, gaps remain in understanding the pharmacokinetics, bioavailability, and safe dosage ranges of the bioactive compounds in Humulus species. Future research should focus on in vivo and clinical studies to validate these effects, explore their potential in functional foods and nutraceuticals, and assess their ecological and environmental impacts for large-scale cultivation. In conclusion, Humulus species represent a versatile and valuable natural resource with significant potential in medicine, agriculture, and industry. Continued research efforts are essential to fully unlock their benefits and integrate them into modern therapeutic and industrial applications.

Keywords:

Hop, Humulus, complementary medicine, medicinal plants, antioxidant

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El-Chaghaby, G. A., Sevindik, E., Sevindik, M., Koçer, O., & Uysal, I. (2025). Humulus species: a traditional medicinal plant and its modern pharmacological importance. Prospects in Pharmaceutical Sciences, 23(4), 20–28. https://doi.org/10.56782/pps.388

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Ghadir A. El-Chaghaby

ghadiraly@yahoo.com

Affiliation:

Bioanalysis Laboratory, Regional Center for Food and Feed, Agricultural Research Center, Giza, Egypt Turkey

Emre Sevindik

ph.d-emre@hotmail.com

Affiliation:

Department of Agricultural Biotechnology, Faculty of Agriculture, Aydın Adnan Menderes University, Türkiye Turkey

Mustafa Sevindik

sevindik27@gmail.com

Affiliation:

a:1:{s:5:"en_US";s:115:"Osmaniye Korkut Ata University, Faculty of Science and Literature, Department of Biology, Osmaniye, 80000, Türkiye";} Turkey

Oguzhan Koçer

oguzhankocer@hotmail.com

Affiliation:

Department of Pharmacy Services, Vocational School of Health Services, Osmaniye Korkut Ata University, Türkiye Turkey

Imran Uysal

uysal-imran@hotmail.com

Affiliation:

Department of Food Processing, Bahçe Vocational School of Higher Education, University of Osmaniye Korkut Ata, Türkiye Turkey

Humulus species: a traditional medicinal plant and its modern pharmacological importance

Ghadir A. El-Chaghaby

Emre Sevindik

Mustafa Sevindik

Oguzhan Koçer

Imran Uysal

Abstract

Keywords:

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